Research reference
Tirzepatide
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Dual GLP-1 / GIP receptor research peptide.
Research profile
Classification
Dual agonist peptide — GIP / GLP-1 receptor (twincretin)
Mechanism of action
39-amino-acid synthetic peptide based on the native GIP sequence with C20 fatty diacid acylation. Exhibits imbalanced agonism — full GIPR activity with partial, biased GLP-1R agonism that favors cAMP generation over β-arrestin recruitment, reducing receptor internalization.
Investigated research applications
- Comparative GIPR vs GLP-1R signaling bias and β-arrestin recruitment assays
- Adipocyte lipid handling and insulin sensitivity studies
- Diet-induced obesity models of body-weight and adiposity change
- Glycemic control and pancreatic islet function research
Commonly reported assay endpoints
cAMP vs β-arrestin bias factorFat mass changeHOMA-IRIslet insulin content
For laboratory research use only. Not a drug, food or cosmetic. Not for human or veterinary diagnostic or therapeutic use.