IGF-1LR3

Classification

Long R3 analog of insulin-like growth factor 1 (83-aa recombinant peptide)

Mechanism of action

IGF-1 LR3 substitutes Arg for Glu at position 3 and adds a 13-residue N-terminal extension, markedly reducing affinity for IGF-binding proteins (IGFBP-1 to -6) and extending circulating half-life. Signals through the IGF-1 receptor tyrosine kinase to activate PI3K–Akt–mTOR and Ras–MAPK cascades governing protein synthesis, proliferation and anti-apoptotic signaling.

Investigated research applications

• IGF-1R binding, autophosphorylation and IGFBP-displacement assays
• Myotube hypertrophy and satellite cell proliferation models
• PI3K/Akt/mTOR pathway activation and protein synthesis studies
• Cell culture supplementation for serum-free proliferation protocols

Commonly reported assay endpoints

For laboratory research use only. Not a drug, food or cosmetic. Not for human or veterinary diagnostic or therapeutic use.